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Interactions médicamenteuses

Apomorphine + Netupitant-palonosetron

Gravité: Contre-indiquée

Apomorphine and Netupitant-palonosetron: contraindicated interaction.

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Résumé

Profound hypotension and loss of consciousness have been reported when apomorphine is given with ondansetron, and the apomorphine label contraindicates 5-HT3 antagonists. Palonosetron is a related 5-HT3 antagonist, so the same risk is assumed by class.

Ce que signifie cette interaction, en termes simples

Apomorphine and Netupitant-palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apomorphine belongs to Central Nervous System; Netupitant-palonosetron belongs to Gastrointestinal Tract.

Niveau de preuve: Low

Pourquoi elle survient

The mechanism is not established; it is thought to involve a pharmacodynamic effect of 5-HT3 antagonism on apomorphine-related hypotension.

Conduite à tenir

Avoid combining apomorphine with 5-HT3 antagonists. Use an antiemetic such as trimethobenzamide for apomorphine-related nausea.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apomorphine with Netupitant-palonosetron?

MediHelp rates the interaction as contraindicated. Apomorphine and Netupitant-palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when apomorphine is given with ondansetron, and the apomorphine label contraindicates 5-HT3 antagonists. Palonosetron is a related 5-HT3 antagonist, so the same risk is assumed by class.

How serious is the interaction between Apomorphine and Netupitant-palonosetron?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining apomorphine with 5-HT3 antagonists. Use an antiemetic such as trimethobenzamide for apomorphine-related nausea.

What other medicines interact with Netupitant-palonosetron?

MediHelp also lists interactions of Netupitant-palonosetron with, for example, Flibanserin, Apalutamide, Avapritinib. The full list is on the Netupitant-palonosetron page.

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