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Interactions médicamenteuses

Apomorphine + Dolasetron

Gravité: Contre-indiquée

Apomorphine and Dolasetron: contraindicated interaction.

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Résumé

Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. Dolasetron also prolongs the QT interval, adding an arrhythmia concern.

Ce que signifie cette interaction, en termes simples

Apomorphine and Dolasetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apomorphine belongs to Central Nervous System; Dolasetron belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Mechanism of the hypotension is not established; additive QT prolongation is also possible.

Conduite à tenir

Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apomorphine with Dolasetron?

MediHelp rates the interaction as contraindicated. Apomorphine and Dolasetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. Dolasetron also prolongs the QT interval, adding an arrhythmia concern.

How serious is the interaction between Apomorphine and Dolasetron?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.

What other medicines interact with Dolasetron?

MediHelp also lists interactions of Dolasetron with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Dolasetron page.

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