Interactions médicamenteuses
Aprepitant + Bosutinib
Gravité: Majeure
Aprepitant and Bosutinib: major interaction.
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Résumé
Bosutinib is metabolized mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Coadministration may raise bosutinib concentrations and increase gastrointestinal, hepatic and other toxicities.
Ce que signifie cette interaction, en termes simples
Aprepitant and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Bosutinib belongs to Oncology.
Pourquoi elle survient
Inhibition of CYP3A4-mediated metabolism of bosutinib by aprepitant.
Conduite à tenir
Avoid moderate CYP3A4 inhibitors where possible and consider an alternative antiemetic. If used, monitor for bosutinib toxicity such as diarrhea and liver enzyme elevations, and adjust the dose as needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Aprepitant
- Aprepitant + Lomitapide Contre-indiquée
- Aprepitant + Pimozide Contre-indiquée
- Aprepitant + Avapritinib Majeure
- Aprepitant + Carbamazepine Majeure
- Aprepitant + Cobicistat Majeure
- Aprepitant + Cobimetinib Majeure
Autres interactions de Bosutinib
- Amiodarone + Bosutinib Majeure
- Apalutamide + Bosutinib Majeure
- Bosentan + Bosutinib Majeure
- Bosutinib + Carbamazepine Majeure
- Bosutinib + Chlorpromazine Majeure
- Bosutinib + Cisapride Majeure
Questions fréquentes
Can I take Aprepitant with Bosutinib?
MediHelp rates the interaction as major. Aprepitant and Bosutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosutinib is metabolized mainly by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Coadministration may raise bosutinib concentrations and increase gastrointestinal, hepatic and other toxicities.
How serious is the interaction between Aprepitant and Bosutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid moderate CYP3A4 inhibitors where possible and consider an alternative antiemetic. If used, monitor for bosutinib toxicity such as diarrhea and liver enzyme elevations, and adjust the dose as needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
