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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Aprepitant + Cobicistat

Gravité: Majeure

Aprepitant and Cobicistat: major interaction.

Dernière mise à jour

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Résumé

Cobicistat is a strong CYP3A inhibitor and can substantially increase aprepitant exposure. This may worsen aprepitant adverse effects. Aprepitant in turn may modestly raise levels of other CYP3A substrates in the regimen.

Ce que signifie cette interaction, en termes simples

Aprepitant and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Aprepitant belongs to Gastrointestinal Tract; Cobicistat belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Cobicistat strongly inhibits CYP3A4, the main enzyme clearing aprepitant.

Conduite à tenir

Avoid the combination where possible, or use the single-dose aprepitant regimen with monitoring for adverse effects. Consider an alternative antiemetic such as a 5-HT3 antagonist with dexamethasone adjusted for CYP3A inhibition.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aprepitant with Cobicistat?

MediHelp rates the interaction as major. Aprepitant and Cobicistat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A inhibitor and can substantially increase aprepitant exposure. This may worsen aprepitant adverse effects. Aprepitant in turn may modestly raise levels of other CYP3A substrates in the regimen.

How serious is the interaction between Aprepitant and Cobicistat?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the single-dose aprepitant regimen with monitoring for adverse effects. Consider an alternative antiemetic such as a 5-HT3 antagonist with dexamethasone adjusted for CYP3A inhibition.

What other medicines interact with Aprepitant?

MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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