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Interactions médicamenteuses

Aripiprazole + Arsenic trioxide

Gravité: Majeure

Aripiprazole and Arsenic trioxide: major interaction.

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Résumé

Arsenic trioxide causes marked QT prolongation and torsades de pointes. Aripiprazole has a small QT liability, so the effects may be additive, although aripiprazole is among the lower-risk antipsychotics.

Ce que signifie cette interaction, en termes simples

Aripiprazole and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Aripiprazole belongs to Central Nervous System; Arsenic trioxide belongs to Oncology.

Niveau de preuve: Low

Pourquoi elle survient

Additive prolongation of cardiac repolarization.

Conduite à tenir

Avoid other QT-prolonging drugs during arsenic trioxide therapy where alternatives exist. If aripiprazole must continue, monitor ECG and keep potassium and magnesium within normal range.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aripiprazole with Arsenic trioxide?

MediHelp rates the interaction as major. Aripiprazole and Arsenic trioxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide causes marked QT prolongation and torsades de pointes. Aripiprazole has a small QT liability, so the effects may be additive, although aripiprazole is among the lower-risk antipsychotics.

How serious is the interaction between Aripiprazole and Arsenic trioxide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid other QT-prolonging drugs during arsenic trioxide therapy where alternatives exist. If aripiprazole must continue, monitor ECG and keep potassium and magnesium within normal range.

What other medicines interact with Aripiprazole?

MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.

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