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Interactions médicamenteuses

Aripiprazole + Thioridazine

Gravité: Contre-indiquée

Aripiprazole and Thioridazine: contraindicated interaction.

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Résumé

Thioridazine and aripiprazole each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.

Ce que signifie cette interaction, en termes simples

Aripiprazole and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Aripiprazole belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QTc prolongation through hERG potassium channel blockade

Conduite à tenir

Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aripiprazole with Thioridazine?

MediHelp rates the interaction as contraindicated. Aripiprazole and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine and aripiprazole each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.

How serious is the interaction between Aripiprazole and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.

What other medicines interact with Thioridazine?

MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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