Interactions médicamenteuses
Artemether / lumefantrine + Eslicarbazepine
Gravité: Majeure
Artemether / lumefantrine and Eslicarbazepine: major interaction.
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Résumé
Eslicarbazepine can lower artemether and lumefantrine concentrations by inducing CYP3A4. Subtherapeutic antimalarial exposure risks treatment failure and recrudescence.
Ce que signifie cette interaction, en termes simples
Artemether / lumefantrine and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Eslicarbazepine induces CYP3A4, increasing the metabolism of artemether and lumefantrine.
Conduite à tenir
Avoid the combination when possible and use an alternative antimalarial or antiseizure drug. If it cannot be avoided, monitor closely for treatment failure and parasitological response.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Eslicarbazepine
- Eslicarbazepine + Mavacamten Contre-indiquée
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- Bosutinib + Eslicarbazepine Majeure
Questions fréquentes
Can I take Artemether / lumefantrine with Eslicarbazepine?
MediHelp rates the interaction as major. Artemether / lumefantrine and Eslicarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine can lower artemether and lumefantrine concentrations by inducing CYP3A4. Subtherapeutic antimalarial exposure risks treatment failure and recrudescence.
How serious is the interaction between Artemether / lumefantrine and Eslicarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and use an alternative antimalarial or antiseizure drug. If it cannot be avoided, monitor closely for treatment failure and parasitological response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Avapritinib. The full list is on the Eslicarbazepine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
