Interactions médicamenteuses
Eslicarbazepine + Mavacamten
Gravité: Contre-indiquée
Eslicarbazepine and Mavacamten: contraindicated interaction.
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Résumé
Eslicarbazepine inhibits CYP2C19 and induces CYP3A4, which changes mavacamten exposure in unpredictable ways. Raised exposure risks systolic dysfunction and heart failure, whereas lowered exposure reduces efficacy.
Ce que signifie cette interaction, en termes simples
Eslicarbazepine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eslicarbazepine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Pourquoi elle survient
Eslicarbazepine inhibits CYP2C19 and induces CYP3A4, both of which contribute to mavacamten clearance.
Conduite à tenir
Avoid the combination and choose an alternative antiseizure drug. If the pair has been used, monitor LVEF and clinical status closely.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Eslicarbazepine
- Eslicarbazepine + Rilpivirine Contre-indiquée
- Artemether / lumefantrine + Eslicarbazepine Majeure
- Avapritinib + Eslicarbazepine Majeure
- Bedaquiline + Eslicarbazepine Majeure
- Benzhydrocodone / acetaminophen + Eslicarbazepine Majeure
- Bosutinib + Eslicarbazepine Majeure
Autres interactions de Mavacamten
- Apalutamide + Mavacamten Contre-indiquée
- Carbamazepine + Mavacamten Contre-indiquée
- Clarithromycin + Mavacamten Contre-indiquée
- Dexlansoprazole + Mavacamten Contre-indiquée
- Efavirenz + Mavacamten Contre-indiquée
- Enzalutamide + Mavacamten Contre-indiquée
Questions fréquentes
Can I take Eslicarbazepine with Mavacamten?
MediHelp rates the interaction as contraindicated. Eslicarbazepine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eslicarbazepine inhibits CYP2C19 and induces CYP3A4, which changes mavacamten exposure in unpredictable ways. Raised exposure risks systolic dysfunction and heart failure, whereas lowered exposure reduces efficacy.
How serious is the interaction between Eslicarbazepine and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an alternative antiseizure drug. If the pair has been used, monitor LVEF and clinical status closely.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Rilpivirine, Artemether / lumefantrine, Avapritinib. The full list is on the Eslicarbazepine page.
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