Interactions médicamenteuses
Artesunate + Eltrombopag
Gravité: Modérée
Artesunate and Eltrombopag: moderate interaction.
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Résumé
Artesunate is converted to dihydroartemisinin (DHA), which is cleared by glucuronidation through UGT1A9 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so DHA exposure could rise, with possible increased adverse effects.
Ce que signifie cette interaction, en termes simples
Artesunate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Eltrombopag belongs to Miscellaneous.
Pourquoi elle survient
Eltrombopag inhibits UGT enzymes in vitro and may reduce glucuronidation of the active metabolite DHA.
Conduite à tenir
Monitor for artesunate adverse effects such as hemolysis and hepatic changes, and monitor platelet counts and liver tests. No empirical dose change is recommended.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Eltrombopag
- Alpelisib + Eltrombopag Modérée
- Aluminum hydroxide + Eltrombopag Modérée
- Amobarbital + Eltrombopag Modérée
- Atazanavir + Eltrombopag Modérée
- Atorvastatin + Eltrombopag Modérée
- Berotralstat + Eltrombopag Modérée
Autres interactions de Artesunate
- Artesunate + Rifampicin Majeure
- Artesunate + Carbamazepine Modérée
- Artesunate + Imatinib Modérée
- Artesunate + Nevirapine Modérée
- Artesunate + Phenytoin Modérée
- Artesunate + Regorafenib Modérée
Questions fréquentes
Can I take Artesunate with Eltrombopag?
MediHelp rates the interaction as moderate. Artesunate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artesunate is converted to dihydroartemisinin (DHA), which is cleared by glucuronidation through UGT1A9 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so DHA exposure could rise, with possible increased adverse effects.
How serious is the interaction between Artesunate and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for artesunate adverse effects such as hemolysis and hepatic changes, and monitor platelet counts and liver tests. No empirical dose change is recommended.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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