Drug interactions
Artesunate + Eltrombopag
Severity: Moderate
Artesunate and Eltrombopag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artesunate is converted to dihydroartemisinin (DHA), which is cleared by glucuronidation through UGT1A9 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so DHA exposure could rise, with possible increased adverse effects.
What this interaction means in plain words
Artesunate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Artesunate belongs to Anti Parasitic; Eltrombopag belongs to Miscellaneous.
Why it happens
Eltrombopag inhibits UGT enzymes in vitro and may reduce glucuronidation of the active metabolite DHA.
What to do
Monitor for artesunate adverse effects such as hemolysis and hepatic changes, and monitor platelet counts and liver tests. No empirical dose change is recommended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
- Berotralstat + Eltrombopag Moderate
Other interactions of Artesunate
- Artesunate + Rifampicin Major
- Artesunate + Carbamazepine Moderate
- Artesunate + Imatinib Moderate
- Artesunate + Nevirapine Moderate
- Artesunate + Phenytoin Moderate
- Artesunate + Regorafenib Moderate
Frequently asked questions
Can I take Artesunate with Eltrombopag?
MediHelp rates the interaction as moderate. Artesunate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Artesunate is converted to dihydroartemisinin (DHA), which is cleared by glucuronidation through UGT1A9 and UGT2B7. Eltrombopag inhibits UGT enzymes in vitro, so DHA exposure could rise, with possible increased adverse effects.
How serious is the interaction between Artesunate and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for artesunate adverse effects such as hemolysis and hepatic changes, and monitor platelet counts and liver tests. No empirical dose change is recommended.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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