Interactions médicamenteuses
Asciminib + Clarithromycin
Gravité: Majeure
Asciminib and Clarithromycin: major interaction.
Dernière mise à jour
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Résumé
Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Clarithromycin also inhibits CYP3A4, which may modestly raise asciminib exposure.
Ce que signifie cette interaction, en termes simples
Asciminib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asciminib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
Pourquoi elle survient
Additive QT prolongation, with possible CYP3A4 inhibition by clarithromycin.
Conduite à tenir
Avoid with the higher asciminib dose of 200 mg twice daily. At lower doses, obtain a baseline ECG, monitor ECG and electrolytes, and correct potassium and magnesium.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Asciminib
- Asciminib + Dihydroergotamine Majeure
- Asciminib + Ergotamine Majeure
- Asciminib + Haloperidol Majeure
- Asciminib + Methadone Majeure
- Asciminib + Moxifloxacin Majeure
- Asciminib + Atorvastatin Modérée
Autres interactions de Clarithromycin
- Astemizole + Clarithromycin Contre-indiquée
- Avanafil + Clarithromycin Contre-indiquée
- Cisapride + Clarithromycin Contre-indiquée
- Clarithromycin + Colchicine Contre-indiquée
- Clarithromycin + Conivaptan Contre-indiquée
- Clarithromycin + Dihydroergotamine Contre-indiquée
Questions fréquentes
Can I take Asciminib with Clarithromycin?
MediHelp rates the interaction as major. Asciminib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Clarithromycin also inhibits CYP3A4, which may modestly raise asciminib exposure.
How serious is the interaction between Asciminib and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with the higher asciminib dose of 200 mg twice daily. At lower doses, obtain a baseline ECG, monitor ECG and electrolytes, and correct potassium and magnesium.
What other medicines interact with Asciminib?
MediHelp also lists interactions of Asciminib with, for example, Dihydroergotamine, Ergotamine, Haloperidol. The full list is on the Asciminib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
