Interactions médicamenteuses
Clarithromycin + Conivaptan
Gravité: Contre-indiquée
Clarithromycin and Conivaptan: contraindicated interaction.
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Résumé
Conivaptan is a CYP3A4 substrate and clarithromycin markedly increases its exposure. This may lead to excessive aquaresis, overly rapid sodium correction, and a risk of osmotic demyelination. Labeling contraindicates strong CYP3A4 inhibitors.
Ce que signifie cette interaction, en termes simples
Clarithromycin and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Clarithromycin inhibits CYP3A4 and reduces conivaptan clearance.
Conduite à tenir
Do not coadminister; use an alternative antibiotic and monitor serum sodium closely during conivaptan therapy.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Clarithromycin
- Astemizole + Clarithromycin Contre-indiquée
- Avanafil + Clarithromycin Contre-indiquée
- Cisapride + Clarithromycin Contre-indiquée
- Clarithromycin + Colchicine Contre-indiquée
- Clarithromycin + Dihydroergotamine Contre-indiquée
- Clarithromycin + Dihydroergotamine intranasal Contre-indiquée
Questions fréquentes
Can I take Clarithromycin with Conivaptan?
MediHelp rates the interaction as contraindicated. Clarithromycin and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a CYP3A4 substrate and clarithromycin markedly increases its exposure. This may lead to excessive aquaresis, overly rapid sodium correction, and a risk of osmotic demyelination. Labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Conivaptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic and monitor serum sodium closely during conivaptan therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
