Interactions médicamenteuses
Axicabtagene ciloleucel + Capecitabine
Gravité: Majeure
Axicabtagene ciloleucel and Capecitabine: major interaction.
Dernière mise à jour
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Résumé
Capecitabine can cause lymphopenia and myelosuppression, which may impair collection, expansion and persistence of CAR T cells. It also adds to the infection risk after CAR T therapy.
Ce que signifie cette interaction, en termes simples
Axicabtagene ciloleucel and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Capecitabine belongs to Oncology.
Pourquoi elle survient
Cytotoxic myelosuppression and lymphodepletion may compromise CAR T-cell function and add to immunosuppression.
Conduite à tenir
Avoid capecitabine in the window before leukapheresis and during CAR T recovery unless clearly needed. Coordinate timing with the CAR T team and monitor for infection and cytopenias.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Capecitabine
Autres interactions de Axicabtagene ciloleucel
Questions fréquentes
Can I take Axicabtagene ciloleucel with Capecitabine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Capecitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capecitabine can cause lymphopenia and myelosuppression, which may impair collection, expansion and persistence of CAR T cells. It also adds to the infection risk after CAR T therapy.
How serious is the interaction between Axicabtagene ciloleucel and Capecitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid capecitabine in the window before leukapheresis and during CAR T recovery unless clearly needed. Coordinate timing with the CAR T team and monitor for infection and cytopenias.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Brexucabtagene autoleucel. The full list is on the Capecitabine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
