Interactions médicamenteuses
Capecitabine + Deferiprone
Gravité: Majeure
Capecitabine and Deferiprone: major interaction.
Dernière mise à jour
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Résumé
Capecitabine, a fluorouracil prodrug, can cause myelosuppression, and deferiprone can cause agranulocytosis. Their combination increases the risk of severe neutropenia and infection.
Ce que signifie cette interaction, en termes simples
Capecitabine and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capecitabine belongs to Oncology; Deferiprone belongs to Miscellaneous.
Pourquoi elle survient
Additive myelosuppressive effects on neutrophils.
Conduite à tenir
Avoid the combination when an alternative exists. Otherwise monitor absolute neutrophil count more often and hold deferiprone if neutropenia occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Capecitabine
Autres interactions de Deferiprone
- Clozapine + Deferiprone Contre-indiquée
- Abemaciclib + Deferiprone Majeure
- Acalabrutinib + Deferiprone Majeure
- Ado-trastuzumab emtansine + Deferiprone Majeure
- Ado-trastuzumab + Deferiprone Majeure
- Aldesleukin + Deferiprone Majeure
Questions fréquentes
Can I take Capecitabine with Deferiprone?
MediHelp rates the interaction as major. Capecitabine and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capecitabine, a fluorouracil prodrug, can cause myelosuppression, and deferiprone can cause agranulocytosis. Their combination increases the risk of severe neutropenia and infection.
How serious is the interaction between Capecitabine and Deferiprone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when an alternative exists. Otherwise monitor absolute neutrophil count more often and hold deferiprone if neutropenia occurs.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
