Interactions médicamenteuses
Axitinib + Dicloxacillin
Gravité: Modérée
Axitinib and Dicloxacillin: moderate interaction.
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Résumé
Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
Ce que signifie cette interaction, en termes simples
Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Dicloxacillin belongs to Anti Bacterial.
Pourquoi elle survient
Dicloxacillin induces CYP3A4, increasing the metabolism of axitinib.
Conduite à tenir
Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Dicloxacillin
- Dicloxacillin + Phenindione Majeure
- Atogepant + Dicloxacillin Modérée
- Bcg vaccine live + Dicloxacillin Modérée
- Cholera vaccine + Dicloxacillin Modérée
- Demeclocycline + Dicloxacillin Modérée
- Dicloxacillin + Doxycycline Modérée
Autres interactions de Axitinib
- Amobarbital + Axitinib Majeure
- Apalutamide + Axitinib Majeure
- Atazanavir + Axitinib Majeure
- Axitinib + Carbamazepine Majeure
- Axitinib + Clarithromycin Majeure
- Axitinib + Cobicistat Majeure
Questions fréquentes
Can I take Axitinib with Dicloxacillin?
MediHelp rates the interaction as moderate. Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
How serious is the interaction between Axitinib and Dicloxacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Bcg vaccine live. The full list is on the Dicloxacillin page.
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