Drug interactions
Axitinib + Dicloxacillin
Severity: Moderate
Axitinib and Dicloxacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
What this interaction means in plain words
Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Dicloxacillin belongs to Anti Bacterial.
Why it happens
Dicloxacillin induces CYP3A4, increasing the metabolism of axitinib.
What to do
Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
- Dicloxacillin + Doxycycline Moderate
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Dicloxacillin?
MediHelp rates the interaction as moderate. Axitinib and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicloxacillin is a weak inducer of CYP3A4 and may lower axitinib exposure, which is mainly cleared by CYP3A4/5. Reduced axitinib levels could diminish antitumour efficacy. The clinical effect is probably modest.
How serious is the interaction between Axitinib and Dicloxacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced axitinib response when dicloxacillin is given for more than a short course. Use a non-inducing antibiotic if one is suitable.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Bcg vaccine live. The full list is on the Dicloxacillin page.
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