Interactions médicamenteuses
Bacitracin-neomycin-polymyxin + Capreomycin
Gravité: Majeure
Bacitracin-neomycin-polymyxin and Capreomycin: major interaction.
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Résumé
Capreomycin is nephrotoxic and ototoxic, and neomycin and polymyxin B carry the same risks when absorbed. Combining them can cause additive kidney injury, hearing loss and neuromuscular blockade, especially with large-surface or irrigation use.
Ce que signifie cette interaction, en termes simples
Bacitracin-neomycin-polymyxin and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive nephrotoxicity, ototoxicity and neuromuscular blockade from drugs with overlapping toxicity.
Conduite à tenir
Avoid concurrent systemic or high-absorption use of these agents. If unavoidable, monitor serum creatinine, electrolytes and hearing, and use the shortest possible course.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Majeure
- Atracurium + Bacitracin-neomycin-polymyxin Majeure
- Bacitracin-neomycin-polymyxin + Cidofovir Majeure
- Bacitracin-neomycin-polymyxin + Cisatracurium Majeure
- Bacitracin-neomycin-polymyxin + Pancuronium Majeure
- Bacitracin-neomycin-polymyxin + Rocuronium Majeure
Questions fréquentes
Can I take Bacitracin-neomycin-polymyxin with Capreomycin?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin is nephrotoxic and ototoxic, and neomycin and polymyxin B carry the same risks when absorbed. Combining them can cause additive kidney injury, hearing loss and neuromuscular blockade, especially with large-surface or irrigation use.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Capreomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic or high-absorption use of these agents. If unavoidable, monitor serum creatinine, electrolytes and hearing, and use the shortest possible course.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Cidofovir. The full list is on the Bacitracin-neomycin-polymyxin page.
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