Interactions médicamenteuses
Bcg intravesical live + Cilastatin-imipenem
Gravité: Modérée
Bcg intravesical live and Cilastatin-imipenem: moderate interaction.
Dernière mise à jour
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Résumé
Intravesical BCG is a live attenuated mycobacterium that must remain viable to act. Systemic antibiotics, particularly those with antimycobacterial activity, may reduce its effect. Imipenem has limited mycobacterial activity, but BCG labeling advises postponing unnecessary antimicrobials.
Ce que signifie cette interaction, en termes simples
Bcg intravesical live and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Antibacterial activity may reduce the viability and local immune-stimulating effect of live BCG.
Conduite à tenir
Defer elective antibiotic therapy during BCG instillations where possible. If an infection requires imipenem, consider holding the instillation until treatment is complete.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cilastatin-imipenem
Questions fréquentes
Can I take Bcg intravesical live with Cilastatin-imipenem?
MediHelp rates the interaction as moderate. Bcg intravesical live and Cilastatin-imipenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravesical BCG is a live attenuated mycobacterium that must remain viable to act. Systemic antibiotics, particularly those with antimycobacterial activity, may reduce its effect. Imipenem has limited mycobacterial activity, but BCG labeling advises postponing unnecessary antimicrobials.
How serious is the interaction between Bcg intravesical live and Cilastatin-imipenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Defer elective antibiotic therapy during BCG instillations where possible. If an infection requires imipenem, consider holding the instillation until treatment is complete.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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