Interactions médicamenteuses
Cilastatin-imipenem + Ganciclovir
Gravité: Majeure
Cilastatin-imipenem and Ganciclovir: major interaction.
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Résumé
Generalized seizures have been reported in patients receiving ganciclovir together with imipenem-cilastatin. Both drugs can lower seizure threshold, particularly in renal impairment.
Ce que signifie cette interaction, en termes simples
Cilastatin-imipenem and Ganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cilastatin-imipenem belongs to Anti Bacterial; Ganciclovir belongs to Anti Virals.
Pourquoi elle survient
The mechanism is not well established and is probably additive lowering of seizure threshold.
Conduite à tenir
Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If used, adjust doses for renal function and monitor for neurological toxicity.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cilastatin-imipenem
Autres interactions de Ganciclovir
- Bacitracin + Ganciclovir Majeure
- Didanosine + Ganciclovir Majeure
- Ganciclovir + Imipenem / cilastatin Majeure
- Ganciclovir + Imipenem / cilastatin / relebactam Majeure
- Ganciclovir + Liposomal doxorubicin Majeure
- Ganciclovir + Maribavir Majeure
Questions fréquentes
Can I take Cilastatin-imipenem with Ganciclovir?
MediHelp rates the interaction as major. Cilastatin-imipenem and Ganciclovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Generalized seizures have been reported in patients receiving ganciclovir together with imipenem-cilastatin. Both drugs can lower seizure threshold, particularly in renal impairment.
How serious is the interaction between Cilastatin-imipenem and Ganciclovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless the benefit clearly outweighs the risk, and consider a non-carbapenem antibiotic. If used, adjust doses for renal function and monitor for neurological toxicity.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Valproic acid, Bcg intravesical live. The full list is on the Cilastatin-imipenem page.
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