Interactions médicamenteuses
Benzhydrocodone / acetaminophen + Clorazepate
Gravité: Majeure
Benzhydrocodone / acetaminophen and Clorazepate: major interaction.
Dernière mise à jour
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Résumé
Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. The risk is dose-dependent and is regulated by boxed warnings.
Ce que signifie cette interaction, en termes simples
Benzhydrocodone / acetaminophen and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression from opioid and benzodiazepine receptor effects.
Conduite à tenir
Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contre-indiquée
- Clorazepate + Sodium oxybate Contre-indiquée
- Alfentanil + Clorazepate Majeure
- Alprazolam + Clorazepate Majeure
- Amobarbital + Clorazepate Majeure
- Belladonna and opium + Clorazepate Majeure
Questions fréquentes
Can I take Benzhydrocodone / acetaminophen with Clorazepate?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a benzodiazepine can cause profound sedation, respiratory depression, coma and death. The risk is dose-dependent and is regulated by boxed warnings.
How serious is the interaction between Benzhydrocodone / acetaminophen and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients with no adequate alternatives, using the lowest doses and shortest duration. Monitor for sedation and respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
