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Interactions médicamenteuses

Amobarbital + Clorazepate

Gravité: Majeure

Amobarbital and Clorazepate: major interaction.

Dernière mise à jour

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Résumé

Barbiturates and benzodiazepines both depress the CNS, so combined use can cause profound sedation, respiratory depression and coma. Amobarbital also induces CYP3A4 and may lower exposure to clorazepate's active metabolite, making the net effect less predictable.

Ce que signifie cette interaction, en termes simples

Amobarbital and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amobarbital belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive GABAergic CNS and respiratory depression, plus CYP3A4 induction by amobarbital that increases clearance of the benzodiazepine.

Conduite à tenir

Avoid the combination where possible, or use the lowest doses with close monitoring of sedation and respiratory status. Reassess clorazepate dosing when the barbiturate is started or stopped.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amobarbital with Clorazepate?

MediHelp rates the interaction as major. Amobarbital and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines both depress the CNS, so combined use can cause profound sedation, respiratory depression and coma. Amobarbital also induces CYP3A4 and may lower exposure to clorazepate's active metabolite, making the net effect less predictable.

How serious is the interaction between Amobarbital and Clorazepate?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses with close monitoring of sedation and respiratory status. Reassess clorazepate dosing when the barbiturate is started or stopped.

What other medicines interact with Clorazepate?

MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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