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Interactions médicamenteuses

Berotralstat + Quinidine

Gravité: Majeure

Berotralstat and Quinidine: major interaction.

Dernière mise à jour

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Résumé

Berotralstat inhibits P-gp and CYP3A4, both involved in quinidine disposition, and can increase quinidine levels. Quinidine may also raise berotralstat via P-gp inhibition. Elevated quinidine exposure increases the risk of QT prolongation and arrhythmia, and berotralstat itself prolongs QT at higher doses.

Ce que signifie cette interaction, en termes simples

Berotralstat and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Berotralstat belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Berotralstat inhibits P-gp and CYP3A4, reducing quinidine clearance, while quinidine inhibits P-gp efflux of berotralstat.

Conduite à tenir

Monitor ECG QTc and quinidine concentrations, and reduce the quinidine dose if levels or QTc rise; consider an alternative antiarrhythmic.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Berotralstat with Quinidine?

MediHelp rates the interaction as major. Berotralstat and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits P-gp and CYP3A4, both involved in quinidine disposition, and can increase quinidine levels. Quinidine may also raise berotralstat via P-gp inhibition. Elevated quinidine exposure increases the risk of QT prolongation and arrhythmia, and berotralstat itself prolongs QT at higher doses.

How serious is the interaction between Berotralstat and Quinidine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG QTc and quinidine concentrations, and reduce the quinidine dose if levels or QTc rise; consider an alternative antiarrhythmic.

What other medicines interact with Quinidine?

MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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