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Interactions médicamenteuses

Brentuximab + Dengue vaccine

Gravité: Majeure

Brentuximab and Dengue vaccine: major interaction.

Dernière mise à jour

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Résumé

Brentuximab vedotin is cytotoxic and causes myelosuppression, which can blunt the immune response to vaccination. Dengue vaccine is live attenuated, so replicating vaccine virus could cause disease in an immunocompromised patient.

Ce que signifie cette interaction, en termes simples

Brentuximab and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Niveau de preuve: Moderate

Pourquoi elle survient

Cytotoxic immunosuppression impairs vaccine response and may permit uncontrolled replication of live attenuated virus.

Conduite à tenir

Avoid live dengue vaccine during brentuximab therapy and until immune recovery is documented. Plan vaccination before treatment where feasible.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Brentuximab with Dengue vaccine?

MediHelp rates the interaction as major. Brentuximab and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brentuximab vedotin is cytotoxic and causes myelosuppression, which can blunt the immune response to vaccination. Dengue vaccine is live attenuated, so replicating vaccine virus could cause disease in an immunocompromised patient.

How serious is the interaction between Brentuximab and Dengue vaccine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine during brentuximab therapy and until immune recovery is documented. Plan vaccination before treatment where feasible.

What other medicines interact with Brentuximab?

MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Etrasimod, Idelalisib. The full list is on the Brentuximab page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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