Interactions médicamenteuses
Brentuximab + Idelalisib
Gravité: Majeure
Brentuximab and Idelalisib: major interaction.
Dernière mise à jour
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Résumé
Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
Ce que signifie cette interaction, en termes simples
Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab belongs to Oncology; Idelalisib belongs to Oncology.
Pourquoi elle survient
Strong CYP3A inhibition by idelalisib reduces MMAE metabolism and increases exposure.
Conduite à tenir
Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Brentuximab
- Bleomycin + Brentuximab Contre-indiquée
- Brentuximab + Dengue vaccine Majeure
- Brentuximab + Etrasimod Majeure
- Brentuximab + Levoketoconazole Majeure
- Brentuximab + Nefazodone Majeure
- Brentuximab + Ritonavir Majeure
Autres interactions de Idelalisib
- Alfuzosin + Idelalisib Contre-indiquée
- Cisapride + Idelalisib Contre-indiquée
- Dihydroergotamine + Idelalisib Contre-indiquée
- Dronedarone + Idelalisib Contre-indiquée
- Eletriptan + Idelalisib Contre-indiquée
- Eplerenone + Idelalisib Contre-indiquée
Questions fréquentes
Can I take Brentuximab with Idelalisib?
MediHelp rates the interaction as major. Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
How serious is the interaction between Brentuximab and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
