Interactions médicamenteuses
Buprenorphine + Esketamine
Gravité: Majeure
Buprenorphine and Esketamine: major interaction.
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Résumé
Opioids and esketamine both depress the CNS, and together they raise the risk of profound sedation and respiratory depression. Buprenorphine has a ceiling on respiratory effects, but the risk remains when combined with other depressants.
Ce que signifie cette interaction, en termes simples
Buprenorphine and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Esketamine belongs to Central Nervous System.
Pourquoi elle survient
Additive CNS and respiratory depression via opioid receptor agonism and NMDA antagonism.
Conduite à tenir
Monitor sedation, respiratory rate and oxygen saturation closely during and after esketamine administration, and use the lowest effective buprenorphine dose.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Esketamine
Autres interactions de Buprenorphine
- Alvimopan + Buprenorphine Contre-indiquée
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contre-indiquée
- Buprenorphine + Olanzapine / samidorphan Contre-indiquée
- Buprenorphine + Phenelzine Contre-indiquée
- Buprenorphine + Pimozide Contre-indiquée
- Buprenorphine + Thioridazine Contre-indiquée
Questions fréquentes
Can I take Buprenorphine with Esketamine?
MediHelp rates the interaction as major. Buprenorphine and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and esketamine both depress the CNS, and together they raise the risk of profound sedation and respiratory depression. Buprenorphine has a ceiling on respiratory effects, but the risk remains when combined with other depressants.
How serious is the interaction between Buprenorphine and Esketamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and oxygen saturation closely during and after esketamine administration, and use the lowest effective buprenorphine dose.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
