Interactions médicamenteuses
Buprenorphine long-acting + Gabapentin
Gravité: Majeure
Buprenorphine long-acting and Gabapentin: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Opioids combined with gabapentinoids carry an increased risk of profound sedation, respiratory depression, coma and death. Regulators have issued warnings about this because gabapentin can potentiate opioid-induced respiratory depression.
Ce que signifie cette interaction, en termes simples
Buprenorphine long-acting and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression.
Conduite à tenir
Reserve the combination for patients with inadequate alternatives, using the lowest effective doses. Monitor for sedation and respiratory depression, particularly in those with lung disease, renal impairment or older age.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Gabapentin
- Alprazolam + Gabapentin Majeure
- Amobarbital + Gabapentin Majeure
- Belladonna and opium + Gabapentin Majeure
- Benzhydrocodone / acetaminophen + Gabapentin Majeure
- Brexanolone + Gabapentin Majeure
- Buprenorphine buccal + Gabapentin Majeure
Questions fréquentes
Can I take Buprenorphine long-acting with Gabapentin?
MediHelp rates the interaction as major. Buprenorphine long-acting and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with gabapentinoids carry an increased risk of profound sedation, respiratory depression, coma and death. Regulators have issued warnings about this because gabapentin can potentiate opioid-induced respiratory depression.
How serious is the interaction between Buprenorphine long-acting and Gabapentin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with inadequate alternatives, using the lowest effective doses. Monitor for sedation and respiratory depression, particularly in those with lung disease, renal impairment or older age.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
