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Interactions médicamenteuses

Butorphanol + Sodium oxybate

Gravité: Contre-indiquée

Butorphanol and Sodium oxybate: contraindicated interaction.

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Résumé

Both drugs depress the central nervous system, and combining them can cause profound sedation, respiratory depression, coma and death. Labeling for sodium oxybate generally warns against use with other CNS depressants such as opioids.

Ce que signifie cette interaction, en termes simples

Butorphanol and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Butorphanol belongs to Musculoskeletal; Sodium oxybate belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive pharmacodynamic CNS and respiratory depression.

Conduite à tenir

Avoid the combination. If an opioid is unavoidable, use the lowest dose for the shortest time, and monitor respiratory status and consciousness closely, with consideration of reducing or interrupting oxybate.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Butorphanol with Sodium oxybate?

MediHelp rates the interaction as contraindicated. Butorphanol and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs depress the central nervous system, and combining them can cause profound sedation, respiratory depression, coma and death. Labeling for sodium oxybate generally warns against use with other CNS depressants such as opioids.

How serious is the interaction between Butorphanol and Sodium oxybate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If an opioid is unavoidable, use the lowest dose for the shortest time, and monitor respiratory status and consciousness closely, with consideration of reducing or interrupting oxybate.

What other medicines interact with Butorphanol?

MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Alfentanil, Alprazolam. The full list is on the Butorphanol page.

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