Référentiel des médicaments
Sodium oxybate
Sodium oxybate is a medicine in the class central nervous system. It is used for narcolepsy.
- Classe médicamenteuse: Central Nervous System
- Indications: narcolepsy
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Code ATC
- N07XX04
- Formes courantes
- suspension buvable, solution
- Dosages courants
- 50%
- Interactions connues
- 99 (Contre-indiquée: 17 · Majeure: 79 · Modérée: 3)
- Noms commerciaux
- 3
- Pays et marchés
- 2
Indications
Mécanisme d'action
CNS depressant. Mechanism in narcolepsy is unknown. It is the sodium salt of GHB, a metabolite of GABA; therapeutic effects are hypothesized to be mediated through GABA B actions at noradrenergic, dopaminergic and thalamocortical neurons.
Posologie adulte habituelle (résumé de la notice)
Narcolepsy (cataplexy or EDS): start 4.5 g per night orally in two divided doses (2.25 g at bedtime and 2.25 g 2.5 to 4 hours later); increase by 1.5 g per night at weekly intervals; effective range 6 g to 9 g per night; doses higher than 9 g per night not studied.
Grossesse et allaitement
- Grossesse
- Unknown No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose.
- Allaitement
- Unknown GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
Effets indésirables signalés
- Nausea
- Dizziness
- Vomiting
- Somnolence
- Enuresis
- Tremor
Mises en garde encadrées
- CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
Contre-indications
- Combination with sedative hypnotics.
- Combination with alcohol.
- Succinic semialdehyde dehydrogenase deficiency.
Précautions particulières
- Concurrent use with other CNS depressants may increase risk of respiratory depression, hypotension, profound sedation, syncope and death; consider dose reduction or discontinuation.
- No hazardous activities requiring mental alertness for at least 6 hours after dosing.
- May impair respiratory drive; increased central apneas and desaturation observed in adults and children.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (99)
- Alprazolam + Sodium oxybate Contraindicated
- Amobarbital + Sodium oxybate Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Eszopiclone + Sodium oxybate Contraindicated
- Methadone + Sodium oxybate Contraindicated
- Midazolam + Sodium oxybate Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Sodium oxybate used for?
Sodium oxybate is a medicine in the class central nervous system. It is used for Narcolepsy.
What side effects have been reported with Sodium oxybate?
Nausea, Dizziness, Vomiting, Somnolence, Enuresis, Tremor. Serious warning: CNS depression: Xyrem is a CNS depressant; obtundation and clinically significant respiratory depression occurred in adults at recommended doses.
Can Sodium oxybate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Rat pre/postnatal study showed increased stillbirths and decreased offspring viability and growth at a clinically relevant dose. Breastfeeding: Unknown. GHB is excreted in human milk; insufficient information on infant risk. Weigh breastfeeding benefits against maternal need.
What does Sodium oxybate interact with?
MediHelp lists 99 known interactions for Sodium oxybate. Contraindicated: 17 · Major: 79 · Moderate: 3. The most serious include Alprazolam, Amobarbital, Butorphanol.
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