Interactions médicamenteuses
Candesartan-hydrochlorothiazide + Chlorthalidone
Gravité: Majeure
Candesartan-hydrochlorothiazide and Chlorthalidone: major interaction.
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Résumé
Chlorthalidone and hydrochlorothiazide are both thiazide-type diuretics, so using them together duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia.
Ce que signifie cette interaction, en termes simples
Candesartan-hydrochlorothiazide and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
Pourquoi elle survient
Therapeutic duplication with additive inhibition of the distal tubule sodium-chloride cotransporter.
Conduite à tenir
Avoid concurrent use and keep to a single thiazide-type agent. If both have been used, check electrolytes and renal function.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contre-indiquée
- Candesartan-hydrochlorothiazide + Dofetilide Contre-indiquée
- Candesartan-hydrochlorothiazide + Sparsentan Contre-indiquée
- Acemetacin + Candesartan-hydrochlorothiazide Majeure
- Amifostine + Candesartan-hydrochlorothiazide Majeure
- Amiloride + Candesartan-hydrochlorothiazide Majeure
Autres interactions de Chlorthalidone
Questions fréquentes
Can I take Candesartan-hydrochlorothiazide with Chlorthalidone?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Chlorthalidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorthalidone and hydrochlorothiazide are both thiazide-type diuretics, so using them together duplicates therapy. This increases the risk of hypokalemia, hyponatremia, volume depletion and hyperuricemia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorthalidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep to a single thiazide-type agent. If both have been used, check electrolytes and renal function.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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