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Interactions médicamenteuses

Capreomycin + Tobramycin

Gravité: Majeure

Capreomycin and Tobramycin: major interaction.

Dernière mise à jour

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Résumé

Both drugs are toxic to the kidney and the inner ear, and giving them together adds to the risk of acute kidney injury, hearing loss and vestibular damage. Capreomycin also carries neuromuscular blocking potential, which adds to the risk. The damage can be permanent.

Ce que signifie cette interaction, en termes simples

Capreomycin and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive nephrotoxicity, ototoxicity and neuromuscular blockade through overlapping toxicities.

Conduite à tenir

Avoid concurrent use when alternatives exist. If unavoidable, monitor serum creatinine, tobramycin levels and hearing or vestibular function, and adjust doses to renal function.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Capreomycin with Tobramycin?

MediHelp rates the interaction as major. Capreomycin and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are toxic to the kidney and the inner ear, and giving them together adds to the risk of acute kidney injury, hearing loss and vestibular damage. Capreomycin also carries neuromuscular blocking potential, which adds to the risk. The damage can be permanent.

How serious is the interaction between Capreomycin and Tobramycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when alternatives exist. If unavoidable, monitor serum creatinine, tobramycin levels and hearing or vestibular function, and adjust doses to renal function.

What other medicines interact with Tobramycin?

MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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