Interactions médicamenteuses
Captopril-hydrochlorothiazide + Colestipol
Gravité: Modérée
Captopril-hydrochlorothiazide and Colestipol: moderate interaction.
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Résumé
Colestipol binds hydrochlorothiazide in the gut and reduces its absorption, which can weaken the diuretic and antihypertensive effect. The effect applies to oral dosing when taken together.
Ce que signifie cette interaction, en termes simples
Captopril-hydrochlorothiazide and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Colestipol belongs to Cardiovascular.
Pourquoi elle survient
Bile acid sequestrant binds the thiazide in the gastrointestinal tract, reducing absorption.
Conduite à tenir
Give the combination tablet at least 4 hours before colestipol, or 1 hour before at the minimum, and monitor blood pressure.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contre-indiquée
- Captopril-hydrochlorothiazide + Dofetilide Contre-indiquée
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contre-indiquée
- Aceclofenac + Captopril-hydrochlorothiazide Majeure
- Aldesleukin + Captopril-hydrochlorothiazide Majeure
- Amifostine + Captopril-hydrochlorothiazide Majeure
Autres interactions de Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Modérée
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Modérée
- Atenolol-chlorthalidone + Colestipol Modérée
- Azilsartan-chlorthalidone + Colestipol Modérée
- Candesartan-hydrochlorothiazide + Colestipol Modérée
- Chenodeoxycholic acid + Colestipol Modérée
Questions fréquentes
Can I take Captopril-hydrochlorothiazide with Colestipol?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol binds hydrochlorothiazide in the gut and reduces its absorption, which can weaken the diuretic and antihypertensive effect. The effect applies to oral dosing when taken together.
How serious is the interaction between Captopril-hydrochlorothiazide and Colestipol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the combination tablet at least 4 hours before colestipol, or 1 hour before at the minimum, and monitor blood pressure.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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