Interactions médicamenteuses
Carbamazepine + Linagliptin-metformin
Gravité: Majeure
Carbamazepine and Linagliptin-metformin: major interaction.
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Résumé
Carbamazepine is a strong inducer of CYP3A4 and P-glycoprotein and can substantially lower linagliptin concentrations. This may lead to loss of glycemic efficacy.
Ce que signifie cette interaction, en termes simples
Carbamazepine and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Pourquoi elle survient
Induction of CYP3A4 and P-gp increases linagliptin metabolism and efflux, reducing exposure.
Conduite à tenir
Avoid the combination where possible and use an alternative antidiabetic agent not affected by induction. If co-administered, monitor glucose and HbA1c closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Linagliptin-metformin
Autres interactions de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contre-indiquée
- Cabotegravir + Carbamazepine Contre-indiquée
- Carbamazepine + Delamanid Contre-indiquée
- Carbamazepine + Dienogest / estradiol valerate Contre-indiquée
- Carbamazepine + Doravirine Contre-indiquée
- Carbamazepine + Elbasvir / grazoprevir Contre-indiquée
Questions fréquentes
Can I take Carbamazepine with Linagliptin-metformin?
MediHelp rates the interaction as major. Carbamazepine and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a strong inducer of CYP3A4 and P-glycoprotein and can substantially lower linagliptin concentrations. This may lead to loss of glycemic efficacy.
How serious is the interaction between Carbamazepine and Linagliptin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antidiabetic agent not affected by induction. If co-administered, monitor glucose and HbA1c closely.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Linagliptin-metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
