Drug interactions
Carbamazepine + Linagliptin-metformin
Severity: Major
Carbamazepine and Linagliptin-metformin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong inducer of CYP3A4 and P-glycoprotein and can substantially lower linagliptin concentrations. This may lead to loss of glycemic efficacy.
What this interaction means in plain words
Carbamazepine and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
Induction of CYP3A4 and P-gp increases linagliptin metabolism and efflux, reducing exposure.
What to do
Avoid the combination where possible and use an alternative antidiabetic agent not affected by induction. If co-administered, monitor glucose and HbA1c closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linagliptin-metformin
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Linagliptin-metformin?
MediHelp rates the interaction as major. Carbamazepine and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a strong inducer of CYP3A4 and P-glycoprotein and can substantially lower linagliptin concentrations. This may lead to loss of glycemic efficacy.
How serious is the interaction between Carbamazepine and Linagliptin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antidiabetic agent not affected by induction. If co-administered, monitor glucose and HbA1c closely.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Linagliptin-metformin page.
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