Interactions médicamenteuses
Carbamazepine + Methimazole
Gravité: Majeure
Carbamazepine and Methimazole: major interaction.
Dernière mise à jour
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Résumé
Both drugs can cause bone marrow suppression, including agranulocytosis, so using them together may raise the chance of serious neutropenia. Fever or sore throat may signal a life-threatening infection.
Ce que signifie cette interaction, en termes simples
Carbamazepine and Methimazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Methimazole belongs to Endocrine.
Pourquoi elle survient
Additive pharmacodynamic myelotoxicity; each drug independently carries a risk of idiosyncratic agranulocytosis.
Conduite à tenir
Obtain a baseline and periodic white cell count with differential, and instruct the patient to report fever or sore throat promptly. Stop the thionamide or carbamazepine if neutropenia develops, and consider an alternative anticonvulsant where feasible.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contre-indiquée
- Cabotegravir + Carbamazepine Contre-indiquée
- Carbamazepine + Delamanid Contre-indiquée
- Carbamazepine + Dienogest / estradiol valerate Contre-indiquée
- Carbamazepine + Doravirine Contre-indiquée
- Carbamazepine + Elbasvir / grazoprevir Contre-indiquée
Autres interactions de Methimazole
- Clozapine + Methimazole Majeure
- Methimazole + Propylthiouracil Majeure
- Methimazole + Sodium iodide i-131 Majeure
- Iodinated glycerol + Methimazole Modérée
- Iodine + Methimazole Modérée
- Lycopus + Methimazole Modérée
Questions fréquentes
Can I take Carbamazepine with Methimazole?
MediHelp rates the interaction as major. Carbamazepine and Methimazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause bone marrow suppression, including agranulocytosis, so using them together may raise the chance of serious neutropenia. Fever or sore throat may signal a life-threatening infection.
How serious is the interaction between Carbamazepine and Methimazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline and periodic white cell count with differential, and instruct the patient to report fever or sore throat promptly. Stop the thionamide or carbamazepine if neutropenia develops, and consider an alternative anticonvulsant where feasible.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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