Interactions médicamenteuses
Methimazole + Sodium iodide i-131
Gravité: Majeure
Methimazole and Sodium iodide i-131: major interaction.
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Résumé
Antithyroid drugs reduce thyroid uptake of radioiodine, so the therapeutic radiation dose delivered to the gland may be inadequate. Treatment failure or the need for repeat dosing may result.
Ce que signifie cette interaction, en termes simples
Methimazole and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Methimazole inhibits thyroid peroxidase and hormone synthesis, which lowers thyroidal radioiodine uptake and retention.
Conduite à tenir
Stop methimazole several days before I-131 administration, typically 3 to 4 days per labeling, and do not give them together. Restart afterward according to the treating specialist's plan and monitor thyroid function.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Methimazole
- Carbamazepine + Methimazole Majeure
- Clozapine + Methimazole Majeure
- Methimazole + Propylthiouracil Majeure
- Iodinated glycerol + Methimazole Modérée
- Iodine + Methimazole Modérée
- Lycopus + Methimazole Modérée
Questions fréquentes
Can I take Methimazole with Sodium iodide i-131?
MediHelp rates the interaction as major. Methimazole and Sodium iodide i-131 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antithyroid drugs reduce thyroid uptake of radioiodine, so the therapeutic radiation dose delivered to the gland may be inadequate. Treatment failure or the need for repeat dosing may result.
How serious is the interaction between Methimazole and Sodium iodide i-131?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop methimazole several days before I-131 administration, typically 3 to 4 days per labeling, and do not give them together. Restart afterward according to the treating specialist's plan and monitor thyroid function.
What other medicines interact with Methimazole?
MediHelp also lists interactions of Methimazole with, for example, Carbamazepine, Clozapine, Propylthiouracil. The full list is on the Methimazole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
