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Interactions médicamenteuses

Cefiderocol + Streptomycin

Gravité: Modérée

Cefiderocol and Streptomycin: moderate interaction.

Dernière mise à jour

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Résumé

Streptomycin is nephrotoxic and ototoxic, and any decline in kidney function raises its exposure. Cefiderocol has little direct nephrotoxicity, so the added risk is modest and mainly from renal changes in sick patients.

Ce que signifie cette interaction, en termes simples

Cefiderocol and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefiderocol belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Possible additive nephrotoxicity, with reduced renal clearance of streptomycin if kidney function declines.

Conduite à tenir

Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cefiderocol with Streptomycin?

MediHelp rates the interaction as moderate. Cefiderocol and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is nephrotoxic and ototoxic, and any decline in kidney function raises its exposure. Cefiderocol has little direct nephrotoxicity, so the added risk is modest and mainly from renal changes in sick patients.

How serious is the interaction between Cefiderocol and Streptomycin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.

What other medicines interact with Streptomycin?

MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.

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