Interactions médicamenteuses
Cefoxitin + Kanamycin
Gravité: Modérée
Cefoxitin and Kanamycin: moderate interaction.
Dernière mise à jour
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Résumé
Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
Ce que signifie cette interaction, en termes simples
Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Additive nephrotoxic potential, with aminoglycoside-related tubular injury and ototoxicity possibly aggravated by reduced renal clearance.
Conduite à tenir
Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefoxitin
- Amikacin + Cefoxitin Modérée
- Aztreonam + Cefoxitin Modérée
- Bcg vaccine live + Cefoxitin Modérée
- Cefoxitin + Chloramphenicol Modérée
- Cefoxitin + Cholera vaccine Modérée
- Cefoxitin + Dexamethasone-tobramycin Modérée
Questions fréquentes
Can I take Cefoxitin with Kanamycin?
MediHelp rates the interaction as moderate. Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
How serious is the interaction between Cefoxitin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
