Interactions médicamenteuses
Chloramphenicol + Vincristine
Gravité: Majeure
Chloramphenicol and Vincristine: major interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Chloramphenicol may increase vincristine exposure by CYP3A4 inhibition. This can worsen peripheral neuropathy, constipation or ileus, and other neurotoxic effects.
Ce que signifie cette interaction, en termes simples
Chloramphenicol and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Vincristine belongs to Oncology.
Pourquoi elle survient
Inhibition of CYP3A4 reduces vincristine clearance.
Conduite à tenir
Prefer a non-inhibiting antibiotic. If combined, monitor closely for neurotoxicity and bowel function and adjust vincristine as needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
- Chloramphenicol Capsules BP 250 mg - SmPC sections 4.3/4.5 (class statement: Cytotoxic agents; "- Cytotoxic agents") — electronic medicines compendium (UK SmPC)
Autres interactions de Chloramphenicol
Autres interactions de Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contre-indiquée
- Apalutamide + Vincristine Majeure
- Atazanavir + Vincristine Majeure
- Ceritinib + Vincristine Majeure
- Clarithromycin + Vincristine Majeure
- Cobicistat + Vincristine Majeure
Questions fréquentes
Can I take Chloramphenicol with Vincristine?
MediHelp rates the interaction as major. Chloramphenicol and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol may increase vincristine exposure by CYP3A4 inhibition. This can worsen peripheral neuropathy, constipation or ileus, and other neurotoxic effects.
How serious is the interaction between Chloramphenicol and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inhibiting antibiotic. If combined, monitor closely for neurotoxicity and bowel function and adjust vincristine as needed.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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