Interactions médicamenteuses
Ceritinib + Vincristine
Gravité: Majeure
Ceritinib and Vincristine: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Ceritinib inhibits CYP3A4, which is the main route of vincristine metabolism. Higher vincristine exposure can worsen neurotoxicity, including severe peripheral neuropathy, constipation, and ileus.
Ce que signifie cette interaction, en termes simples
Ceritinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Vincristine belongs to Oncology.
Pourquoi elle survient
Ceritinib inhibits CYP3A4-mediated metabolism of vincristine, raising its plasma concentrations.
Conduite à tenir
Avoid the combination if an alternative exists. If it is unavoidable, monitor closely for neuropathy and constipation and reduce the vincristine dose when toxicity appears.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contre-indiquée
- Apalutamide + Vincristine Majeure
- Atazanavir + Vincristine Majeure
- Chloramphenicol + Vincristine Majeure
- Clarithromycin + Vincristine Majeure
- Cobicistat + Vincristine Majeure
Autres interactions de Ceritinib
- Ceritinib + Cisapride Contre-indiquée
- Ceritinib + Eletriptan Contre-indiquée
- Ceritinib + Flibanserin Contre-indiquée
- Ceritinib + Pimozide Contre-indiquée
- Ceritinib + Thioridazine Contre-indiquée
- Ceritinib + Tolvaptan Contre-indiquée
Questions fréquentes
Can I take Ceritinib with Vincristine?
MediHelp rates the interaction as major. Ceritinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib inhibits CYP3A4, which is the main route of vincristine metabolism. Higher vincristine exposure can worsen neurotoxicity, including severe peripheral neuropathy, constipation, and ileus.
How serious is the interaction between Ceritinib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, monitor closely for neuropathy and constipation and reduce the vincristine dose when toxicity appears.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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