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Interactions médicamenteuses

Chlordiazepoxide + Zuranolone

Gravité: Majeure

Chlordiazepoxide and Zuranolone: major interaction.

Dernière mise à jour

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Résumé

Zuranolone causes CNS depression and impairs driving and psychomotor performance. Adding chlordiazepoxide increases the risk of excessive sedation and impairment.

Ce que signifie cette interaction, en termes simples

Chlordiazepoxide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Chlordiazepoxide belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive CNS depression via positive allosteric modulation of GABA-A receptors by both drugs.

Conduite à tenir

Avoid the combination where possible; if required, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Chlordiazepoxide with Zuranolone?

MediHelp rates the interaction as major. Chlordiazepoxide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes CNS depression and impairs driving and psychomotor performance. Adding chlordiazepoxide increases the risk of excessive sedation and impairment.

How serious is the interaction between Chlordiazepoxide and Zuranolone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if required, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery.

What other medicines interact with Chlordiazepoxide?

MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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