Drug interactions
Chlordiazepoxide + Zuranolone
Severity: Major
Chlordiazepoxide and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes CNS depression and impairs driving and psychomotor performance. Adding chlordiazepoxide increases the risk of excessive sedation and impairment.
What this interaction means in plain words
Chlordiazepoxide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlordiazepoxide belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via positive allosteric modulation of GABA-A receptors by both drugs.
What to do
Avoid the combination where possible; if required, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlordiazepoxide
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Chlordiazepoxide with Zuranolone?
MediHelp rates the interaction as major. Chlordiazepoxide and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes CNS depression and impairs driving and psychomotor performance. Adding chlordiazepoxide increases the risk of excessive sedation and impairment.
How serious is the interaction between Chlordiazepoxide and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if required, consider reducing the zuranolone dose and monitor for sedation. Counsel patients not to drive or operate machinery.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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