Interactions médicamenteuses
Chlorpromazine + Metrizamide
Gravité: Contre-indiquée
Chlorpromazine and Metrizamide: contraindicated interaction.
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Résumé
Intrathecal metrizamide lowers the seizure threshold, and phenothiazines such as chlorpromazine also lower it. Giving them together raises the risk of convulsions after myelography.
Ce que signifie cette interaction, en termes simples
Chlorpromazine and Metrizamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Additive lowering of the seizure threshold; the precise mechanism is not well established.
Conduite à tenir
Stop the phenothiazine at least 48 hours before myelography where feasible, and do not restart it for at least 24 hours afterwards. Use a non-ionic contrast agent suited to intrathecal use, and avoid this combination.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Chlorpromazine
- Chlorpromazine + Dofetilide Contre-indiquée
- Chlorpromazine + Dronedarone Contre-indiquée
- Chlorpromazine + Droperidol Contre-indiquée
- Chlorpromazine + Ibutilide Contre-indiquée
- Chlorpromazine + Panobinostat Contre-indiquée
- Chlorpromazine + Pimozide Contre-indiquée
Questions fréquentes
Can I take Chlorpromazine with Metrizamide?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Metrizamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intrathecal metrizamide lowers the seizure threshold, and phenothiazines such as chlorpromazine also lower it. Giving them together raises the risk of convulsions after myelography.
How serious is the interaction between Chlorpromazine and Metrizamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the phenothiazine at least 48 hours before myelography where feasible, and do not restart it for at least 24 hours afterwards. Use a non-ionic contrast agent suited to intrathecal use, and avoid this combination.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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