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Interactions médicamenteuses

Chlorpromazine + Ibutilide

Gravité: Contre-indiquée

Chlorpromazine and Ibutilide: contraindicated interaction.

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Résumé

Both agents prolong repolarization, and ibutilide already carries a substantial risk of torsades de pointes. Adding chlorpromazine increases the likelihood of life-threatening ventricular arrhythmia.

Ce que signifie cette interaction, en termes simples

Chlorpromazine and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Chlorpromazine belongs to Central Nervous System; Ibutilide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation from cardiac potassium channel blockade.

Conduite à tenir

Avoid giving ibutilide to patients taking chlorpromazine; use an alternative cardioversion strategy or hold the phenothiazine as appropriate.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Chlorpromazine with Ibutilide?

MediHelp rates the interaction as contraindicated. Chlorpromazine and Ibutilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong repolarization, and ibutilide already carries a substantial risk of torsades de pointes. Adding chlorpromazine increases the likelihood of life-threatening ventricular arrhythmia.

How serious is the interaction between Chlorpromazine and Ibutilide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving ibutilide to patients taking chlorpromazine; use an alternative cardioversion strategy or hold the phenothiazine as appropriate.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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