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Interactions médicamenteuses

Cilostazol + Enoxaparin

Gravité: Majeure

Cilostazol and Enoxaparin: major interaction.

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Résumé

Cilostazol inhibits platelet aggregation, and enoxaparin is an anticoagulant, so haemostasis is impaired at two steps. The risk of bleeding is increased, including gastrointestinal and intracranial haemorrhage.

Ce que signifie cette interaction, en termes simples

Cilostazol and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cilostazol belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive impairment of haemostasis: PDE3-mediated antiplatelet effect plus anticoagulation

Conduite à tenir

Combine only when clearly indicated; monitor haemoglobin and for bleeding, and review concurrent antiplatelet or NSAID use.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cilostazol with Enoxaparin?

MediHelp rates the interaction as major. Cilostazol and Enoxaparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cilostazol inhibits platelet aggregation, and enoxaparin is an anticoagulant, so haemostasis is impaired at two steps. The risk of bleeding is increased, including gastrointestinal and intracranial haemorrhage.

How serious is the interaction between Cilostazol and Enoxaparin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combine only when clearly indicated; monitor haemoglobin and for bleeding, and review concurrent antiplatelet or NSAID use.

What other medicines interact with Enoxaparin?

MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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