Interactions médicamenteuses
Citalopram + Methylene blue
Gravité: Contre-indiquée
Citalopram and Methylene blue: contraindicated interaction.
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Résumé
Methylene blue inhibits MAO-A and, with SSRIs like citalopram, can cause severe serotonin syndrome. Reactions can include altered mental status, hyperthermia, seizures and neuromuscular abnormalities.
Ce que signifie cette interaction, en termes simples
Citalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Reversible MAO-A inhibition by methylene blue added to SSRI-mediated serotonin reuptake blockade.
Conduite à tenir
Avoid unless methylene blue is needed for an emergency; then stop citalopram and monitor for CNS toxicity. Resume only after the labeled interval after the last methylene blue dose.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Citalopram
- Cisapride + Citalopram Contre-indiquée
- Citalopram + Dronedarone Contre-indiquée
- Citalopram + Escitalopram Contre-indiquée
- Citalopram + Isocarboxazid Contre-indiquée
- Citalopram + Phenelzine Contre-indiquée
- Citalopram + Pimozide Contre-indiquée
Questions fréquentes
Can I take Citalopram with Methylene blue?
MediHelp rates the interaction as contraindicated. Citalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A and, with SSRIs like citalopram, can cause severe serotonin syndrome. Reactions can include altered mental status, hyperthermia, seizures and neuromuscular abnormalities.
How serious is the interaction between Citalopram and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for an emergency; then stop citalopram and monitor for CNS toxicity. Resume only after the labeled interval after the last methylene blue dose.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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