Interactions médicamenteuses
Citric acid / glucono-delta-lactone / magnesium carbonate + Misoprostol
Gravité: Modérée
Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol: moderate interaction.
Dernière mise à jour
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Résumé
Magnesium-containing preparations can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacid use may also modestly lower systemic exposure to misoprostol acid.
Ce que signifie cette interaction, en termes simples
Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Additive osmotic laxative effect of magnesium with misoprostol-induced intestinal secretion and motility, plus possible reduced absorption of the active acid.
Conduite à tenir
Prefer an aluminum- or calcium-based antacid without magnesium if one is required. Monitor for diarrhea and dehydration.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Misoprostol
Questions fréquentes
Can I take Citric acid / glucono-delta-lactone / magnesium carbonate with Misoprostol?
MediHelp rates the interaction as moderate. Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing preparations can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacid use may also modestly lower systemic exposure to misoprostol acid.
How serious is the interaction between Citric acid / glucono-delta-lactone / magnesium carbonate and Misoprostol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an aluminum- or calcium-based antacid without magnesium if one is required. Monitor for diarrhea and dehydration.
What other medicines interact with Misoprostol?
MediHelp also lists interactions of Misoprostol with, for example, Oxytocin, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Misoprostol page.
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