Référentiel des médicaments
Misoprostol
Misoprostol is a medicine in the class gastrointestinal tract. It is used for peptic ulcer.
- Classe médicamenteuse: Gastrointestinal Tract
- Indications: peptic ulcer
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Gastrointestinal Tract
- Formes courantes
- comprimé, solution
- Dosages courants
- 200 mcg, 10 g/100 ml, 25 mcg
- Interactions connues
- 5 (Majeure: 1 · Modérée: 4)
- Noms commerciaux
- 8
- Pays et marchés
- 3
Indications
Mécanisme d'action
Synthetic prostaglandin E analogue parent drug that is rapidly deesterified to misoprostol acid (active metabolite) and replaces protective prostaglandins consumed with therapies that inhibit prostaglandin synthesis; inhibits gastric acid secretion and protects gastric mucosa.
Posologie adulte habituelle (résumé de la notice)
NSAID-Induced Ulcer (Prophylaxis): 200 mcg PO q6hr with food; may be decreased to 100 mcg q6hr if higher dose is not tolerated; last dose to be administered at bedtime
Grossesse et allaitement
- Grossesse
- Unsafe Contraindicated in pregnancy except licensed obstetric uses: it can cause miscarriage, uterine rupture and bleeding, and 1st-trimester exposure is linked to skull, facial, cranial nerve and limb defects. Women who could become pregnant need reliable contraception.
- Allaitement
- Safe Converted to an active acid that reaches milk only in very low amounts, and prostaglandins occur naturally in milk. LactMed: amounts are trivial, no special precautions; postpartum use is fine. US label: use with caution.
Effets indésirables signalés
- Headache
- Diarrhea
- Abdominal pain
Contre-indications
- Pregnancy when used to reduce risk of NSAID-induced ulcers
- Hypersensitivity to misoprostol, prostaglandins, or prostaglandin analogues
Précautions particulières
- Misoprostol may cause birth defects, abortion (sometimes incomplete), premature labor or rupture of the uterus if given to pregnant women.
- Misoprostol should be taken only according to the directions given by a physician.
- For hospital use only if misoprostol were to be used for cervical ripening, induction of labor, or for the treatment of serious post-partum hemorrhage.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (5)
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Misoprostol used for?
Misoprostol is a medicine in the class gastrointestinal tract. It is used for Peptic ulcer, Pregnancy termination.
What side effects have been reported with Misoprostol?
Headache, Diarrhea, Abdominal pain.
Can Misoprostol be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated in pregnancy except licensed obstetric uses: it can cause miscarriage, uterine rupture and bleeding, and 1st-trimester exposure is linked to skull, facial, cranial nerve and limb defects. Women who could become pregnant need reliable contraception. Breastfeeding: Safe. Converted to an active acid that reaches milk only in very low amounts, and prostaglandins occur naturally in milk. LactMed: amounts are trivial, no special precautions; postpartum use is fine. US label: use with caution.
What does Misoprostol interact with?
MediHelp lists 5 known interactions for Misoprostol. Major: 1 · Moderate: 4. The most serious include Oxytocin, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate.
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