Drug interactions
Clarithromycin + Conivaptan
Severity: Contraindicated
Clarithromycin and Conivaptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 substrate and clarithromycin markedly increases its exposure. This may lead to excessive aquaresis, overly rapid sodium correction, and a risk of osmotic demyelination. Labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Clarithromycin and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Clarithromycin inhibits CYP3A4 and reduces conivaptan clearance.
What to do
Do not coadminister; use an alternative antibiotic and monitor serum sodium closely during conivaptan therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine intranasal Contraindicated
Frequently asked questions
Can I take Clarithromycin with Conivaptan?
MediHelp rates the interaction as contraindicated. Clarithromycin and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a CYP3A4 substrate and clarithromycin markedly increases its exposure. This may lead to excessive aquaresis, overly rapid sodium correction, and a risk of osmotic demyelination. Labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Conivaptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic and monitor serum sodium closely during conivaptan therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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