Interactions médicamenteuses
Conivaptan + Ketoconazole
Gravité: Contre-indiquée
Conivaptan and Ketoconazole: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Ketoconazole markedly increases conivaptan exposure and the combination is contraindicated in labeling. Excess conivaptan can cause overly rapid rise in serum sodium, with risk of osmotic demyelination, as well as hypotension and infusion-site reactions. Patients with hyponatremia are most at risk.
Ce que signifie cette interaction, en termes simples
Conivaptan and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Ketoconazole is a strong CYP3A4 inhibitor, and conivaptan is a CYP3A4 substrate, so clearance falls and exposure increases.
Conduite à tenir
Do not use together. If an azole antifungal is needed, consider one without strong CYP3A4 inhibition, or select alternative hyponatremia therapy.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
Autres interactions de Ketoconazole
- Alfuzosin + Ketoconazole Contre-indiquée
- Alprazolam + Ketoconazole Contre-indiquée
- Avanafil + Ketoconazole Contre-indiquée
- Dihydroergotamine intranasal + Ketoconazole Contre-indiquée
- Dihydroergotamine + Ketoconazole Contre-indiquée
- Disopyramide + Ketoconazole Contre-indiquée
Questions fréquentes
Can I take Conivaptan with Ketoconazole?
MediHelp rates the interaction as contraindicated. Conivaptan and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly increases conivaptan exposure and the combination is contraindicated in labeling. Excess conivaptan can cause overly rapid rise in serum sodium, with risk of osmotic demyelination, as well as hypotension and infusion-site reactions. Patients with hyponatremia are most at risk.
How serious is the interaction between Conivaptan and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If an azole antifungal is needed, consider one without strong CYP3A4 inhibition, or select alternative hyponatremia therapy.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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