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Interactions médicamenteuses

Dihydroergotamine + Ketoconazole

Gravité: Contre-indiquée

Dihydroergotamine and Ketoconazole: contraindicated interaction.

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Résumé

Ketoconazole markedly raises dihydroergotamine concentrations. This can cause severe peripheral and cerebral vasospasm and ischemia, including limb and bowel ischemia, and is a labeled contraindication.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dihydroergotamine belongs to Central Nervous System; Ketoconazole belongs to Anti Fungals.

Niveau de preuve: High

Pourquoi elle survient

Strong inhibition of CYP3A4 by ketoconazole reduces the first-pass and systemic metabolism of dihydroergotamine.

Conduite à tenir

Do not combine. Use a non-ergot migraine treatment, or an antifungal that does not strongly inhibit CYP3A4, if dihydroergotamine is needed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dihydroergotamine with Ketoconazole?

MediHelp rates the interaction as contraindicated. Dihydroergotamine and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly raises dihydroergotamine concentrations. This can cause severe peripheral and cerebral vasospasm and ischemia, including limb and bowel ischemia, and is a labeled contraindication.

How serious is the interaction between Dihydroergotamine and Ketoconazole?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-ergot migraine treatment, or an antifungal that does not strongly inhibit CYP3A4, if dihydroergotamine is needed.

What other medicines interact with Ketoconazole?

MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.

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